Human microglia are the primary immune cells in the central nervous system (CNS) and play a vital role in maintaining homeostasis, responding to infections, and participating in neuroinflammatory responses. Understanding the biology of microglia is crucial for unveiling their role in neurodegenerative diseases, psychiatric disorders, and brain injuries. Immortalized Human Microglia-SV40 (HMC-3) represents a significant advancement in researching these cells, providing a model that retains the essential characteristics of primary human microglia while allowing for extensive experimentation. What are HMC-3 Cells?HMC-3 cells are a human microglial cell line that has been immortalized through the introduction of the simian virus 40 (SV40) large T-antigen. This genetic modification enables the cells to proliferate indefinitely while preserving their microglial properties, making them valuable for laboratory studies. HMC-3 cells exhibit several characteristics typical of primary microglia, including: Morphological features such as ramified processes.Expression of microglial markers like Iba1 and CD11b.The ability to respond to inflammatory stimuli and produce cytokines.
- Current Events
- Upcoming Events
- Past Events